PRP for Thin Endometrium: A New Approach to Enhance Implantation

 


For many women undergoing fertility treatments, a thin endometrium becomes a frustrating obstacle. Despite hormonal therapies or supplements, the uterine lining sometimes fails to reach the optimal thickness for embryo implantation.
In recent years, Platelet-Rich Plasma (PRP) has emerged as a promising, natural approach — harnessing the body’s own healing power to improve endometrial receptivity and increase the chances of successful pregnancy.

Condition Overview

The endometrium is the inner lining of the uterus where an embryo must attach to establish pregnancy. A thickness of 7–8 mm or more is generally considered ideal for implantation.
However, conditions such as Asherman’s syndrome, repeated curettage, chronic inflammation, or hormonal imbalance can lead to a persistently thin lining.
Conventional treatments — including estrogen therapy, sildenafil (Viagra), or G-CSF infusion — often yield inconsistent results, leaving patients with few effective options.

How PRP Helps 🌿

PRP is derived from the patient’s own blood, concentrated to contain a high number of platelets and growth factors. When injected into the uterine cavity, these bioactive components can help regenerate the endometrial tissue and enhance its blood supply.

Key growth factors and their functions include:

  • VEGF (Vascular Endothelial Growth Factor): Promotes formation of new blood vessels.

  • PDGF (Platelet-Derived Growth Factor): Stimulates cell proliferation and repair.

  • EGF (Epidermal Growth Factor): Encourages epithelial cell regeneration.

  • TGF-β (Transforming Growth Factor Beta): Regulates inflammation and tissue remodeling.

These combined effects help create a thicker, more receptive uterine lining, increasing the potential for embryo implantation.

Scientific Evidence 🔬

Recent clinical studies highlight PRP’s potential:

  • Chang et al., 2019 (Taiwan): 80% of women with previously thin endometrium achieved >7 mm thickness after PRP infusion, with significantly higher implantation rates compared to controls.

  • Singh et al., 2020 (India): Endometrial thickness increased by an average of 1.8 mm after PRP treatment in patients unresponsive to estrogen therapy.

  • Kim et al., 2022 (Korea): Improved blood flow and receptivity markers were observed in endometrial biopsies post-PRP.

These findings support PRP as a safe, autologous, and effective method for women facing implantation failure due to poor endometrial development.
(References: Chang Y et al., Taiwan J Obstet Gynecol 2019; Singh N et al., J Hum Reprod Sci 2020; Kim JH et al., Reprod Biomed Online 2022.)

Indications / Ideal Candidates 👩‍🦰

PRP therapy may be considered for women who:

  • Have thin endometrium (<7 mm) resistant to hormonal treatment.

  • Experience repeated implantation failure (RIF) after IVF cycles.

  • Suffer from Asherman’s syndrome or post-curettage endometrial damage.

  • Seek a natural, autologous approach with minimal side effects.

PRP may not be suitable for patients with active uterine infections, clotting disorders, or severe systemic illness.

Procedure & Timeline 🩸

  1. Blood Collection: Blood is collected

  2. PRP Preparation: The blood is processed using a sterile centrifuge kit (e.g., TriCell PRP) to separate and concentrate platelets.

  3. Intrauterine Infusion: PRP is gently infused into the uterine cavity via a catheter.

  4. Repeat Sessions: Typically performed 1–2 times per cycle, often before embryo transfer.

  5. Recovery: No anesthesia or downtime is required; normal activities can resume immediately.

Patients usually notice improved endometrial thickness within a few days to a week, depending on their individual condition.


PRP offers a refreshing new path for women facing persistent implantation challenges. By gently awakening the body’s own regenerative capacity, it nurtures a healthier endometrial environment — one that truly welcomes new life.

This approach isn’t just about science; it’s about restoring possibility, confidence, and hope to those who’ve tried everything else.
For many, PRP is not merely another procedure — it’s a chance to begin again, naturally and beautifully.


TriCell PRP: A Decade of Global Excellence Since 2012

Pioneering regenerative medicine for over a decade, TriCell PRP stands as the global leader in Double-Spin PRP technology, trusted across Europe, Asia-Pacific, and the Middle East.

Superior Double-Spin Technology

  • Achieves up to 6.7x to 9x platelet concentration
  • Delivers consistent, reproducible results
  • Features advanced closed-system design

The TriCell Advantage

Unmatched Performance

  • Maximum platelet recovery
  • Optimal growth factor preservation
  • Superior concentration control

Global Recognition

  • CE marked for European markets
  • PMDA approved in Japan
  • TGA certified in Australia
  • CFDA approved in China
  • Registered across Middle East and Southeast Asia

Setting the Gold Standard

TriCell's innovative Double-Spin system delivers precisely what matters most: higher platelet concentrations, better clinical outcomes, and enhanced healing potential. Choose the system that healthcare professionals worldwide trust for superior regenerative results.Experience the difference with TriCell PRP - Where precision meets excellence in regenerative


Do you have any questions? Feel free to contact us! info@rev-med.co.kr



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